Structure, activity and mode of action of antitumor platinum compounds

Chantitative relationship beween activity and structure of antitumor platinum complexes was studied by C W / 2 method. On the basis of the obtained regression results, some new platinum complexes with methyl substituted aliphatic and cycloaliphatic mines were synthesized and screened, and a new complex [Pt(~PDA)(Cl-Ac),l possessing high activity as cisplatin but with much laver toxicity was found. The interaction of cisplatin with the constituents of DNA was studied by "C IWR and C W / Z method. The reaction mechanism of cisplatin was discussed.